Socio-Behavioral Challenges to HIV Vaccine Trials: Literature Review
نویسندگان
چکیده
Introduction: Social and behavioral factors have the potential to affect and inform both the implementation of HIV vaccine trials and the uptake of an eventual HIV vaccine. The growing number of ongoing phase I/II HIV vaccine trials underscores the need for a review of factors affecting the conduct of these trials. Methods: Major databases (PubMed, Cochrane, and Google Search Engine) were searched for relevant articles published in English in the last 10 years on social and behavioral issues affecting HIV vaccine trials. Key search terms applied included: HIV/AIDS, vaccine, microbicides, and recruitment, participation in trials, social harm, adolescent, community, ethics, consent, sexual behavior, acceptability, feasibility, motivation, key populations, vaccine-induced seropositivity, and vaccine trials. The review process was further informed by searches of the reference lists from publications
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